Abstract Background Betaine, an osmoprotective compatible solute, has been used to improve l-threonine production in engineered Escherichia coli l-threonine producer.Betaine supplementation upregulates the expression of zwf encoding glucose-6-phosphate dehydrogenase, leading to the increase of NADPH, which is beneficial for l-threonine production.I
KLRG1 marks tumor-infiltrating CD4 T cell subsets associated with tumor progression and immunotherapy response
Current methods for biomarker discovery and target identification in immuno-oncology rely on static snapshots of tumor immunity.To thoroughly characterize the temporal nature of antitumor immune responses, we developed a 34-parameter spectral flow cytometry panel and performed high-throughput analyses in critical contexts.We leveraged two distinct
Transition from Fire-Dependent Open Forests: Alternative Ecosystem States in the Southeastern United States
Land use and fire exclusion have influenced ecosystems worldwide, resulting in alternative ecosystem states.Here, I provide two examples from the southeastern United States of fire-dependent open pine and pine-oak forest loss and examine dynamics of elbeco adu ripstop pants the replacement forests, given continued long-term declines in foundation l
Evaluation of Evapotranspiration for Exorheic Catchments of China during the GRACE Era: From a Water Balance Perspective
Evapotranspiration (ET) is usually difficult to estimate at the regional scale due to scarce direct measurements.This study uses the water balance equation to calculate the regional ET with observations of precipitation, runoff, and terrestrial water storage changes (TWSC) in nine exorheic catchments of China.We compared the regional ET estimates f
Morphological and structural aspects of the extremely halophilic archaeon Haloquadratum walsbyi.
Ultrathin lagoon (snes square cell Haloquadratum walsbyi from the Archaea domain are the most abundant microorganisms in the hypersaline water of coastal salterns and continental salt lakes.In this work, we explore the cell surface of these microorganisms using amplitude-modulation atomic-force microscopy in nearly physiological conditions.We demon